It is nearly impossible to imagine modern medicine without the use of nuclear technologies, the introduction of which has led to the emergence of new methods of prevention, diagnosis and treatment of various diseases, as well as reduced mortality rates among patients and improved the quality of life of patients with diseases in the field of oncology, cardiology, neurology and others. The purpose of this article is to systematize the principles of the organization of architectural space-planning solutions based on the studied experience of the constructed nuclear medicine facilities. The methodology of this research constitutes an analysis of statistical data and academic papers, in which the authors examine the core process equipment used at nuclear medicine facilities, the main architectural typological zones of nuclear medicine facilities, and highlight the requirements to the premises in which the source of ionizing radiation is located. In addition to the analysis of academic papers, the methodology of this research includes the analysis of practical experience in the architectural design and construction of nuclear medicine facilities, as a result of which the authors analyzed space-planning and architectural solutions used in the design and construction of nuclear medicine facilities. As part of this article, the authors present, in particular, an analysis of the experience of personal design of a number of Russian nuclear medicine facilities. Furthermore, special attention in the article is paid to the principles of architectural and planning solutions for children’s medical institutions (in particular, with oncological specialization). The result of the research is to build up a sketch model of the space-planning solution of the nuclear medicine facility as a multi-purpose facility, to determine the principles that affect the formation of space-planning solutions. The research is aimed at forming a space-planning solution for a multi-purpose nuclear medicine facility, taking into account the possibility of increasing its capacity during operation.