The article presents the results of research on the complex processing of powdered man-made serpentinite waste formed during the enrichment of chrysotile raw materials in order to obtain high-purity magnesium compounds and assess the potential of their use in the production of building materials. The relevance of the work is due to the need to dispose of accumulated waste and expand the raw material base for the construction industry within the framework of the principles of circular economy. The developed technology includes the stages of acidic leaching of magnesium from PTW with sulfuric acid, neutralization and purification of the solution using thermally activated PTW (TA-PTW) and subsequent precipitation of the target products. It was found that thermal activation of waste at 750 °C leads to dehydroxylation and the formation of highly reactive phases, forsterite and periclase, which significantly increases their sorption activity. The optimal leaching regime is recognized as the use of 0.7 stoichiometrically normal amount of H₂so₄, which makes it possible to extract 82.5% of magnesium from the amount of acid introduced into the solution. The combined use of the initial and thermally activated PTW provides a degree of magnesium extraction of 52.3% of its total content in the system and effective purification of the magnesium sulfate solution from impurities of iron, aluminum, chromium and nickel. Sequential precipitation from the purified solution made it possible to obtain high–purity magnesium hydroxide with a calcium content of 0.0110%, and its subsequent calcination - magnesium oxide with a calcium content of 0.0187%. Special attention is paid to the prospects of practical application of synthesized compounds in the construction industry. It is shown that magnesium sulfate can be used as a modifying additive in cements and as a sealer for magnesia binders. Magnesium hydroxide is an effective flame retardant filler, and magnesium oxide is the main component for the production of flame–resistant and moisture-resistant magnesia binders and plates such as glass-magnesium sheets. Thus, the work demonstrates not only the technical feasibility of highly efficient processing of serpentinite waste, but also the significant resource potential of the resulting magnesium compounds for creating modern building materials with improved performance characteristics.