In the sharply continental and hot climate of Kazakhstan, improving building energy efficiency requires adaptive composite envelope systems capable of dynamically responding to external thermal loads. This study provides experimental validation of a newly developed adaptive energy-efficient wall assembly with alternating air channels and a radiant barrier, previously proposed and numerically investigated by the authors. The experiments were conducted in a climatic chamber using a full-scale 3×3 m wall fragment under two operating modes: cold conditions (–14.3 °C) and hot conditions (+26.4 °C with exterior cladding heated up to +46 °C). Interlayer temperatures, heat flux density, and thermal bridging in the bracket zone were measured, and both calculated and effective thermal transmittance resistance values were determined in accordance with regulatory requirements. The experimental results demonstrated strong agreement with numerical simulations: deviations in interlayer temperatures did not exceed 3-7%, while heat flux density differed by 6-9%. The wall configuration Scheme 3/50/75/50 exhibited pronounced adaptive behavior; switching to the ventilation mode during the hot period reduced heat flux density by up to 14% and decreased the temperature gradient within the air channel by an average of 3-5 °C. Under cold conditions, the system increased thermal resistance by up to 18% compared with assemblies without a reflective layer. The obtained effective thermal resistance values comply with the building standards of the Republic of Kazakhstan and confirm the energy efficiency of the wall system for operation in extreme climates. Overall, the experimental validation confirms the reliability of the model and the high practical applicability of the adaptive wall technology. The findings provide a scientifically grounded basis for the development of façade design standards optimized for Central Asian climates and demonstrate the potential for implementation in both new construction and retrofit projects.